HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-benzyl-4-{N-methyl-N-[4-(p-fluorophenyl)-4-oxobutyl]aminomethyl}piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4'-Fluoro-4-iodobutyrophenone | HCID 3016232 | — |
| Reactant | 1-(1-Benzylpiperidin-4-yl)-N-methylmethanamine | HCID 18351312 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-benzyl-4-{N-methyl-N-[4-(p-fluorophenyl)-4-oxobutyl]aminomethyl}piperidine | HCID 19091421 | 77% |
Reaction Steps
Following the procedure of step F of Example 3, starting from 1-benzyl-4-(methylaminomethyl)piperidine and 1-iodo-3-[(p-fluorophenyl)carbonyl]propane, in the presence of potassium carbonate and in acetone as solvent, the desired compound is obtained in the form of an oil, in a yield of 77%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05298503 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-ffa7310223904dd0938c803145b556a9 |
| Source note | uspto-grants-1994_03 |