Potassium Carbonate → 1-benzyl-4-{N-methyl-N-[4-(p-fluorophenyl)-4-oxobutyl]aminomethyl}piperidine

HRID 487870Notes

Reaction equation

HRID 487870 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][CH3:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.I[CH2:18][CH2:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1)=[O:22].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]([CH3:16])[CH2:18][CH2:19][CH2:20][C:21]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)=[O:22])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 30162324'-Fluoro-4-iodobutyrophenoneHCID 183513121-(1-Benzylpiperidin-4-yl)-N-methylmethanamine

Product 1

HCID 190914211-benzyl-4-{N-methyl-N-[4-(p-fluorophenyl)-4-oxobutyl]aminomethyl}piperidineYield 77%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Following the procedure of step F of Example 3, starting from 1-benzyl-4-(methylaminomethyl)piperidine and 1-iodo-3-[(p-fluorophenyl)carbonyl]propane, in the presence of potassium carbonate and in acetone as solvent, the desired compound is obtained in the form of an oil, in a yield of 77%.

Sources & evidence

ORD record
ord-ffa7310223904dd0938c803145b556a9
Source dataset
uspto-grants-1994_03
Patent number
US05298503

Reaction notes

Loading…