反应详情

A suspension of 0.765 g of the product of Example 1 in 20 ml of 1,2-dichloroethane is sonicated under argon for 18 hours with 0.517 g of manganese dioxide. An additional 2 g of manganese dioxide is added and sonication continued for 2 hours. The reaction reaction mixture is filtered through diatomaceous earth which is washed with 500 ml of methylene chloride. The filtrate is concentrated in vacuo to give 0.696 g of the desired product as a solid. FAB MASS SPEC 685(M+Na).

1. customsonication
2. customThe reaction reaction mixture
3. filtrationis filtered through diatomaceous earth which
4. washis washed with 500 ml of methylene chloride
5. concentrationThe filtrate is concentrated in vacuo