Thionyl Chloride → 4-Chloro-2-methoxybenzoyl chloride

HRID 487993Notes

Reaction equation

HRID 487993 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH3:12])[C:5](=[CH:9][CH:10]=1)[C:6](O)=[O:7].S(Cl)([Cl:15])=O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[C:4]([O:11][CH3:12])[CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 936824-Chloro-o-anisic acid

Product 1

HCID 221424504-Chloro-2-methoxybenzoyl chloride

Procedure

120 ml of thionyl chloride was dropwise added at room temperature to 75 g of 4-chloro-2-anisic acid, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated for crystallization. The crystal was used for the subsequent reaction without purification.

Workup

  1. concentrationThe reaction mixture was concentrated for crystallization
  2. customThe crystal was used for the subsequent reaction without purification

Sources & evidence

ORD record
ord-f1053cecc089414eb6eb9c52d3d61ee5
Source dataset
uspto-grants-1994_03
Patent number
US05298518

Reaction notes

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