HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-(2-methoxy-2-oxoethyl)-N-[3-(octadecyloxy)-5-(phenylmethoxy)benzoyl]glycine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Methyl 2-[(2-methoxy-2-oxoethyl)amino]acetate | HCID 428827 | — |
| Reactant | 3-(Octadecyloxy)-5-(phenylmethoxy)benzoic acid | HCID 19389046 | — |
| Product | N-(2-methoxy-2-oxoethyl)-N-[3-(octadecyloxy)-5-(phenylmethoxy)benzoyl]glycine methyl ester | HCID 19091826 | — |
Reaction Steps
Conversion of 3-(octadecyloxy)-5-(phenylmethoxy)benzoic acid to the acid chloride with thionyl chloride followed by treatment with dimethyl iminodiacetate gave N-(2-methoxy-2-oxoethyl)-N-[3-(octadecyloxy)-5-(phenylmethoxy)benzoyl]glycine methyl ester as an oil after chromatography on 50 g of silica gel using 25% ethyl acetate-hexane. The structure was confirmed by the nmr spectrum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05298652 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-a640b00347b44a50a9d126925ce2722f |
| Source note | uspto-grants-1994_03 |