反应详情

A mixture of 2.0 g (11.9 mmol) of 2,5-dihydroxybenzoic acid methyl ester, 4.55 g (13.1 mmol) of 1-bromooctadecane and 1.9 g (13.7 mmol) of potassium carbonate in 50 ml of acetone was stirred at reflux for 24 hours. The solvent was removed at reduced pressure and the residue was treated with water. The product was extracted with ethyl acetate and the dried extract was concentrated to a solid which was recrystallized from ethyl acetate-hexane to give 3.5 g (70% yield, mp 53°-54°) of 2-hydroxy-5-(octadecyloxy)benzoic acid methyl ester.

1. temperatureat reflux for 24 hours
2. customThe solvent was removed at reduced pressure
3. additionthe residue was treated with water
4. extractionThe product was extracted with ethyl acetate
5. extractionthe dried extract
6. concentrationwas concentrated to a solid which
7. customwas recrystallized from ethyl acetate-hexane