反应详情

A mixture of 0.60 g of N-[5-(octadecyloxy)-2-(phenylmethoxy) benzoyl]-N-[2-(phenylmethoxy)-2-oxoethyl]glycine phenylmethyl ester and 0.20 g of 10% palladium on carbon in 20 ml of THF was stirred under a hydrogen atmosphere at room temperature for 23 hours. The catalyst was removed by filtration and the filtrate was concentrated at reduced pressure to a solid which was triturated with ether to give 0.27 g (68% yield, mp 128°-132°) of N-(carboxymethyl)-N-[2-hydroxy-5-(octadecyloxy)benzoyl]glycine.

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated at reduced pressure to a solid which
3. customwas triturated with ether