Diethyl iminodiacetate → N-(2-ethoxy-2-oxoethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine ethyl ester
Reaction equation
[CH2:1]([O:11][C:12]1[CH:13]=[CH:14][C:15]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:16]([CH:20]=1)[C:17](Cl)=[O:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[NH:29]([CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[CH2:34]([O:33][C:31](=[O:32])[CH2:30][N:29]([CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])[C:17](=[O:18])[C:16]1[CH:20]=[C:12]([O:11][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH:13]=[CH:14][C:15]=1[O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH3:35]Participants
3
Procedure
The reaction of 5-(decyloxy)-2-(phenylmethoxy)benzoic acid chloride with diethyl iminodiacetate under conditions described in Example 80 gave N-(2-ethoxy-2-oxoethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine ethyl ester (82% yield, mp 37°-38°).
Sources & evidence
- ORD record
- ord-5b56015db2c4441386c93dbf195ce385
- Source dataset
- uspto-grants-1994_03
- Patent number
- US05298652
Reaction notes
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