Sodium Hydroxide → N-(carboxymethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine
Reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:42])[CH2:7][N:8]([CH2:36][C:37]([O:39]CC)=[O:38])[C:9](=[O:35])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH:13]=[CH:12][C:11]=1[O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)C>>[C:37]([CH2:36][N:8]([C:9](=[O:35])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH:13]=[CH:12][C:11]=1[O:27][CH2:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[CH2:7][C:6]([OH:42])=[O:5])([OH:39])=[O:38]Participants
3
Procedure
Sodium hydroxide hydrolysis of N-(2-ethoxy-2-oxoethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine ethyl ester under conditions described in Example 81 gave N-(carboxymethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine (94% yield, mp 74°-78°).
Sources & evidence
- ORD record
- ord-9e16c53460e647da80258ffb231ab7f3
- Source dataset
- uspto-grants-1994_03
- Patent number
- US05298652
Reaction notes
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