Sodium Hydroxide → 5-[[6-([1,1'-Biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy)benzoic acid

HRID 488324Notes

Reaction equation

[OH-].[Na+].C[O:4][C:5](=[O:40])[C:6]1[CH:11]=[C:10]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:22][CH:21]=2)[CH:9]=[CH:8][C:7]=1[O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[C:23]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:22]=[CH:21][C:20]([O:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][O:12][C:10]2[CH:9]=[CH:8][C:7]([O:32][CH2:33][C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)=[C:6]([CH:11]=2)[C:5]([OH:40])=[O:4])=[CH:25][CH:24]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 54022805HCID 54022805, compound

Product 1

HCID 190918695-[[6-([1,1'-Biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy)benzoic acidYield 96%

Procedure

Sodium hydroxide hydrolysis of 5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy)benzoic acid methyl ester as described in Example 60 gave 5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy)benzoic acid (96% yield, mp 131°-133°).

Sources & evidence

ORD record: ord-78eaf07b5b034d7c9736d93ff02701db
Source dataset: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05298652

Reaction notes

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