HRID488325

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID80502

Glycine, N-(2-ethoxy-2-oxoethyl)-, ethyl ester

C8H15NO4

结构：O=C(Cl)c1cc(OCCCCCCOc2ccc(-c3ccccc3)cc2)ccc1OCc1ccccc1

HCID53865506

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CN(CC(=O)OCC)C(=O)c1cc(OCCCCCCOc2ccc(-c3ccccc3)cc2)ccc1OCc1ccccc1

HCID19091786

未命名化合物

收率 74%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226206

未命名化合物

PROCEDURE

实验过程

The reaction of 5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy)benzoic acid chloride with diethyl iminodiacetate under conditions described in Example 80 gave, after purification by HPLC using 25% ethyl acetate-hexane, N-(2-ethoxy-2-oxoethyl)-N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy) benzoyl]glycine ethyl ester (74% yield, mp 60°-62° ). The structure was confirmed by nmr and mass spectra.

WORKUP

后处理

customgave
customafter purification by HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6139681721a7472588a3ae0918464f2c
来源数据集: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05298652
来源说明: uspto-grants-1994_03

反应 SMILES

[C:1]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:6]=[CH:5][C:4]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:16]=[CH:17][C:18]([O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[C:19]([CH:23]=2)[C:20](Cl)=[O:21])=[CH:3][CH:2]=1.[NH:38]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41]>C(OCC)(=O)C.CCCCCC>[CH2:43]([O:42][C:40](=[O:41])[CH2:39][N:38]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[C:20](=[O:21])[C:19]1[CH:23]=[C:15]([O:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][O:7][C:4]2[CH:5]=[CH:6][C:1]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:2][CH:3]=2)[CH:16]=[CH:17][C:18]=1[O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:44]