HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl iminodiacetate → N-(2-ethoxy-2-oxoethyl)-N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy) benzoyl]glycine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl iminodiacetate | HCID 80502 | — |
| Reactant | HCID 53865506 | HCID 53865506 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | N-(2-ethoxy-2-oxoethyl)-N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy) benzoyl]glycine ethyl ester | HCID 19091786 | 74% |
Reaction Steps
The reaction of 5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy)benzoic acid chloride with diethyl iminodiacetate under conditions described in Example 80 gave, after purification by HPLC using 25% ethyl acetate-hexane, N-(2-ethoxy-2-oxoethyl)-N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy) benzoyl]glycine ethyl ester (74% yield, mp 60°-62° ). The structure was confirmed by nmr and mass spectra.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05298652 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-6139681721a7472588a3ae0918464f2c |
| Source note | uspto-grants-1994_03 |