Sodium Hydroxide → HCID 19091856, compound

HRID 488326Notes

Reaction equation

[OH-].[Na+].C([O:5][C:6](=[O:51])[CH2:7][N:8]([CH2:45][C:46]([O:48]CC)=[O:47])[C:9](=[O:44])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)[CH:13]=[CH:12][C:11]=1[O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)C>>[C:27]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:26]=[CH:25][C:24]([O:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][O:16][C:14]2[CH:13]=[CH:12][C:11]([O:36][CH2:37][C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)=[C:10]([CH:15]=2)[C:9]([N:8]([CH2:7][C:6]([OH:51])=[O:5])[CH2:45][C:46]([OH:48])=[O:47])=[O:44])=[CH:29][CH:28]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 19091786N-(2-ethoxy-2-oxoethyl)-N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy) benzoyl]glycine ethyl ester

Product 1

HCID 19091856HCID 19091856, compoundYield 82%

Procedure

Sodium hydroxide hydrolysis of N-(2-ethoxy-2-oxoethyl)-N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy)benzoyl]glycine ethyl ester under conditions described in Example 81 gave N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2(phenylmethoxy)benzoyl]-N-(carboxymethyl)glycine (82% yield, mp 98°-100° ).

Sources & evidence

ORD record: ord-fd2273131079485e8f25b98abd290c58
Source dataset: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05298652

Reaction notes

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