HRID488326

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)CN(CC(=O)OCC)C(=O)c1cc(OCCCCCCOc2ccc(-c3ccccc3)cc2)ccc1OCc1ccccc1

HCID19091786

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CN(CC(=O)O)C(=O)c1cc(OCCCCCCOc2ccc(-c3ccccc3)cc2)ccc1OCc1ccccc1

HCID19091856

未命名化合物

收率 82%

PROCEDURE

实验过程

Sodium hydroxide hydrolysis of N-(2-ethoxy-2-oxoethyl)-N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2-(phenylmethoxy)benzoyl]glycine ethyl ester under conditions described in Example 81 gave N-[5-[[6-([1,1'-biphenyl]-4-yloxy)hexyl]oxy]-2(phenylmethoxy)benzoyl]-N-(carboxymethyl)glycine (82% yield, mp 98°-100° ).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fd2273131079485e8f25b98abd290c58
来源数据集: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05298652
来源说明: uspto-grants-1994_03

反应 SMILES

[OH-].[Na+].C([O:5][C:6](=[O:51])[CH2:7][N:8]([CH2:45][C:46]([O:48]CC)=[O:47])[C:9](=[O:44])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)[CH:13]=[CH:12][C:11]=1[O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)C>>[C:27]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:26]=[CH:25][C:24]([O:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][O:16][C:14]2[CH:13]=[CH:12][C:11]([O:36][CH2:37][C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)=[C:10]([CH:15]=2)[C:9]([N:8]([CH2:7][C:6]([OH:51])=[O:5])[CH2:45][C:46]([OH:48])=[O:47])=[O:44])=[CH:29][CH:28]=1