Methyl Gentisate → 2-Hydroxy-5-[(12-phenoxydodecyl)oxy]benzoic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:5]=1[OH:11].[O:13]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8]([O:10][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][O:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:7]=[CH:6][C:5]=1[OH:11]Participants
3
Procedure
The reaction of 2,5-dihydroxybenzoic acid methyl ester with 12-phenoxydodecyl bromide under condition described in Example 101 gave 2-hydroxy-5-[(12-phenoxydodecyl)oxy]benzoic acid methyl ester (75% yield, mp 61°-64° ).
Sources & evidence
- ORD record
- ord-582dfdeab3954227ad404ba348fbf280
- Source dataset
- uspto-grants-1994_03
- Patent number
- US05298652
Reaction notes
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