HRID488330

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID80502

Glycine, N-(2-ethoxy-2-oxoethyl)-, ethyl ester

C8H15NO4

结构：O=C(Cl)c1cc(OCCCCCCCCCCCCOc2ccccc2)ccc1OCc1ccccc1

HCID54160397

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CN(CC(=O)OCC)C(=O)c1cc(OCCCCCCCCCCCCOc2ccccc2)ccc1OCc1ccccc1

HCID19091873

未命名化合物

收率 56%

PROCEDURE

实验过程

The reaction of 5-[(12-phenoxydodecyl)oxy]-2-(phenylmethoxy) benzoic acid chloride with diethyl iminodiacetate under conditions described in Example 80 gave N-(2-ethoxy-2-oxoethyl)-N-[5-[(12-phenoxydodecyl)oxy]-2-(phenylmethoxy)benzoyl]glycine ethyl ester (56% yield, mp 49°-50° ). The structure was confirmed by nmr and mass spectra.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-becde61c4bb64533b1e0a9076d398588
来源数据集: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05298652
来源说明: uspto-grants-1994_03

反应 SMILES

[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:22]=[CH:23][C:24]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[C:25]([CH:29]=1)[C:26](Cl)=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:38]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41]>>[CH2:43]([O:42][C:40](=[O:41])[CH2:39][N:38]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[C:26](=[O:27])[C:25]1[CH:29]=[C:21]([O:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:22]=[CH:23][C:24]=1[O:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH3:44]