Sodium Hydroxide → HCID 19091799, compound
Reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:51])[CH2:7][N:8]([CH2:45][C:46]([O:48]CC)=[O:47])[C:9](=[O:44])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:13]=[CH:12][C:11]=1[O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)C>>[C:46]([CH2:45][N:8]([C:9](=[O:44])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:13]=[CH:12][C:11]=1[O:36][CH2:37][C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)[CH2:7][C:6]([OH:51])=[O:5])([OH:48])=[O:47]Participants
3
Procedure
Sodium hydroxide hydrolysis of N-(2-ethoxy-2-oxoethyl)-N-[5-[(12-phenoxydodecyl)oxy]-2-(phenylmethoxy)benzoyl]glycine ethyl ester using conditions described in Example 81 gave N-(carboxymethyl)-N-[5-[(12-phenoxydodecyl)oxy]-2-(phenylmethoxy)benzoyl]glycine (65% yield, mp 70°-75°).
Sources & evidence
- ORD record
- ord-145c3033d5b94bc79405a3a55acd8060
- Source dataset
- uspto-grants-1994_03
- Patent number
- US05298652
Reaction notes
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