Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 69793101 | HCID 69793101 | 69% |
Reaction Steps
6-chloronicotinic acid (4.5 g) was dissolved in methanol (50 ml), treated with 33% methylamine in ethanol solution (25 ml) and heated in a sealed bomb at 140° C. for 18 hours. The mixture was cooled and evaporated to dryness. Trituration with 1:1 methanol/diethyl ether gave the title compound (3.7 g, 69%). MS (+ve is an electrospray) m/z 153 (MH+. 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06972297B2 |
|---|
| Source dataset | uspto-grants-2005_12 |
|---|
| ORD ID | ord-6879020bee7841ceba48257edced9fac |
|---|
| Source note | uspto-grants-2005_12 |
|---|
