Methylamine → HCID 69793101, compound

HRID 488459Notes

Reaction equation

HRID 488459 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH3:11][NH2:12]>CO.C(O)C>[ClH:1].[CH3:11][NH:12][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 792226-Chloronicotinic acid

Product 1

HCID 69793101HCID 69793101, compoundYield 69%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Conditions

Temperature
140 °C

Procedure

6-chloronicotinic acid (4.5 g) was dissolved in methanol (50 ml), treated with 33% methylamine in ethanol solution (25 ml) and heated in a sealed bomb at 140° C. for 18 hours. The mixture was cooled and evaporated to dryness. Trituration with 1:1 methanol/diethyl ether gave the title compound (3.7 g, 69%). MS (+ve is an electrospray) m/z 153 (MH+. 100%).

Workup

  1. temperatureThe mixture was cooled
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-6879020bee7841ceba48257edced9fac
Source dataset
uspto-grants-2005_12
Patent number
US06972297B2

Reaction notes

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