Bromomethylcyclopropane → HCID 22742638, compound

HRID 48848Notes

Reaction equation

HRID 48848 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:5][CH:6]1[C:15]2[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([O:16][CH3:17])[CH:14]=2)[CH2:9][CH2:8][N:7]1[CH2:20][C:21]([NH:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22].[CH:36]1([CH2:39]Br)[CH2:38][CH2:37]1>>[CH:36]1([CH2:39][O:1][C:2]2[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=2[O:34][CH3:35])[CH2:5][CH:6]2[C:15]3[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([O:16][CH3:17])[CH:14]=3)[CH2:9][CH2:8][N:7]2[CH2:20][C:21]([NH:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[CH2:38][CH2:37]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 227426492-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

Product 1

HCID 22742638HCID 22742638, compound

Procedure

prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with cyclopropyl-methyl bromide

Sources & evidence

ORD record
ord-0253e914219d44948dd2d65d46c5d509
Source dataset
uspto-grants-2004_03
Patent number
US06703392B2

Reaction notes

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