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温度

0 °C

A mixture of sodium metal (1.27 g, 0.055 mol) and MeOH (250 mL) was stirred at 0° C. for 10 minutes. This solution was added to a solution of 2-fluoro-5-nitrobenzoic acid methyl ester (10.0 g, 0.046 mol) in MeOH (250 mL), and the mixture was stirred for 20 minutes at 0° C. to 5° C. The reaction mixture was then allowed to warm to room temperature and stir for 2 hours. The mixture was then filtered to give an off-white precipitate. Recrystallization with CHCl3 (70 ml) yielded an off-white crystalline solid, 1.825 g (0.008 mol, 17%) of the title compound.

1. stirringthe mixture was stirred for 20 minutes at 0° C. to 5° C
2. temperatureto warm to room temperature
3. stirringstir for 2 hours
4. filtrationThe mixture was then filtered
5. customto give an off-white precipitate
6. customRecrystallization with CHCl3 (70 ml)