HRID488531

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1

HCID6029

Uridine

C9H12N2O6

HCID9550

Diazomethane

CH2N2

PRODUCTS

生成物

结构：CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1ccc(=O)[nH]c1=O

HCID102212

2'-O-Methyluridine

C10H14N2O6

收率 58%

PROCEDURE

实验过程

Robins et al., 1974 J. Org. Chem. 39, 1891, describe the treatment of a methanolic solution of uridine with diazomethane (in glyme) in the presence of stannous chloride dihydrate (in methanol) to synthesize 2′-O-methyluridine (58% yield). This reaction also yielded a significant fraction (28%) of 3′-O-methyluridine which is purified away from the 2′-O-methyl form by chromatography.