Uridine → 2'-O-Methyluridine

Participants

Reaction Steps

Robins et al., 1974 J. Org. Chem. 39, 1891, describe the treatment of a methanolic solution of uridine with diazomethane (in glyme) in the presence of stannous chloride dihydrate (in methanol) to synthesize 2′-O-methyluridine (58% yield). This reaction also yielded a significant fraction (28%) of 3′-O-methyluridine which is purified away from the 2′-O-methyl form by chromatography.

Provenance & Evidence