HCID 86585324, compound → HCID 86585323, compound

HRID 488649Notes

Reaction equation

HRID 488649 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([NH:15][C@H:16]([C:20]([O:22][CH3:23])=[O:21])[CH2:17][S:18][CH3:19])=[O:14])=O)(C)(C)C>Cl.O1CCOCC1>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([NH:15][C@H:16]([C:20]([O:22][CH3:23])=[O:21])[CH2:17][S:18][CH3:19])=[O:14]

Participants

4

Reactant 1

HCID 86585324HCID 86585324, compound

Product 1

HCID 86585323HCID 86585323, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The t-butyl carbamate from Example 7J was taken up in 4N HCl in dioxane and left at r.t. for 2 hours. The solvent was then removed under reduced pressure and the residue was evaporated with acetonitrile twice and pumped under high vacuum. The resulting amine hydrochloride salt was used directly for the coupling.

Workup

  1. customThe solvent was then removed under reduced pressure
  2. customthe residue was evaporated with acetonitrile twice

Sources & evidence

ORD record
ord-1a9e9a22facb41a4b33d8d0083b03129
Source dataset
uspto-grants-2005_12
Patent number
US06972340B2

Reaction notes

Loading…