反应详情

To a mixture of ethyl 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyrate (2.1 g) in ethanol (10 ml) was added a solution of sodium hydroxide (0.26 g) dissolved into water (10 ml). After heated on hot water bath for 5 minutes, the mixture was cooled by adding ice-water and was made acidic by addition of hydrochloric acid, followed by being extracted with ethyl acetate. The obtained layer was washed with water, dried over sodium sulfate and concentrated. The resultant residue was separated and purified through silica-gel column chromatography (eluting with ethanol:methylene chloride=3:100) to give the title compound (1.3 g, 65.2%) as colorless crystal, mp 79-81° C.

1. temperatureAfter heated on hot water bath for 5 minutes
2. temperaturethe mixture was cooled
3. extractionby being extracted with ethyl acetate
4. washThe obtained layer was washed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. customThe resultant residue was separated
8. custompurified through silica-gel column chromatography (eluting with ethanol:methylene chloride=3:100)