3-(1-Methylpyrrolidin-2-yl)pyridine → HCID 85074186, compound

HRID 488702Notes

Reaction equation

HRID 488702 reaction equation
[N:1]1[CH:6]=[C:5]([CH:7]2[CH2:12][CH2:11][CH2:10][N:8]2[CH3:9])[CH:4]=[CH:3][CH:2]=1.[CH3:13][C:14]1([CH3:24])[C:20]([NH:22][CH3:23])([CH3:21])[CH:18]2[CH2:19][CH:15]1[CH2:16][CH2:17]2>CCCCCC>[N:1]1[CH:6]=[C:5]([CH:7]2[CH2:12][CH2:11][CH2:10][N:8]2[CH3:9])[CH:4]=[CH:3][CH:2]=1.[CH3:13][C:14]1([CH3:24])[C:20]([NH:22][CH3:23])([CH3:21])[CH:18]2[CH2:19][CH:15]1[CH2:16][CH2:17]2

Participants

4

Reactant 2

HCID 9423-(1-Methylpyrrolidin-2-yl)pyridine4×HCID 4032Mecamylamine4×

Product 1

HCID 85074186HCID 85074186, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Nicotine and mecamylamine were added to a hexane solution of Dow Corning BIO-PSA amine compatible silicone pressure sensitive adhesive. Two batches were made: one contained approximately 10% nicotine and 6.4% mecamylamine based on the total dry weight of the adhesive and the two drugs; and a second contained approximately 10% nicotine and 4.2% mecamylamine, based on the total dry weight of the adhesive and the two drugs. The batches were separately coated onto a 3M Scotchpak 1109 polyester/polyoefin backing film at 9.6 mg/cm2 (0.96 mg/cm2 nicotine, 0.61 mg/cm2 mecamylamine, 8.03 mg/cm2 adhesive for the first batch; 0.96 mg/cm2 nicotine, 0.40 mg/cm2 mecamylamine, 8.24 mg/cm2 adhesive for the second batch) and then dried at 30–40° C. for about 2 min.

Workup

  1. dry with material0.96 mg/cm2 nicotine, 0.40 mg/cm2 mecamylamine, 8.24 mg/cm2 adhesive for the second batch) and then dried at 30–40° C. for about 2 min.

Sources & evidence

ORD record
ord-da50336a33da4c0bb3d2bf80e1481ee7
Source dataset
uspto-grants-2005_12
Patent number
US06974588B1

Reaction notes

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