3-(1-Methylpyrrolidin-2-yl)pyridine → HCID 85074186, compound

Participants

Reaction Steps

Nicotine and mecamylamine were added to a hexane solution of Dow Corning BIO-PSA amine compatible silicone pressure sensitive adhesive. Two batches were made: one contained approximately 10% nicotine and 6.4% mecamylamine based on the total dry weight of the adhesive and the two drugs; and a second contained approximately 10% nicotine and 4.2% mecamylamine, based on the total dry weight of the adhesive and the two drugs. The batches were separately coated onto a 3M Scotchpak 1109 polyester/polyoefin backing film at 9.6 mg/cm2 (0.96 mg/cm2 nicotine, 0.61 mg/cm2 mecamylamine, 8.03 mg/cm2 adhesive for the first batch; 0.96 mg/cm2 nicotine, 0.40 mg/cm2 mecamylamine, 8.24 mg/cm2 adhesive for the second batch) and then dried at 30–40° C. for about 2 min.

Provenance & Evidence