反应详情

温度

40 °C

Compound 10b (4.00 g, 13.9 mmol) was dissolved in toluene (0.14 L) under Ar(g). DABCO (1.56 g, 13.9 mmol) was added, and the mixture was heated at 40° C. for 4 h. Solvent was removed under reduced pressure, and the residue was dissolved in CH2Cl2 and washed with both 1 N HCl and saturated brine. The organic layer was dried over MgSO4(s), and the solvent was removed under reduced pressure. Compound 11b was isolated in 95% yield, and was used without further purification. Spectral Data. As reported previously.4b

1. customSolvent was removed under reduced pressure
2. dissolutionthe residue was dissolved in CH2Cl2
3. washwashed with both 1 N HCl and saturated brine
4. dry with materialThe organic layer was dried over MgSO4(s)
5. customthe solvent was removed under reduced pressure