反应详情

温度

50 °C

To a stirred solution of 2-cyanothioacetamide (1.4 g, 14 mmol) and 2,4-nonanedione (2.0 g, 13 mmol) in anhydrous EtOH (40 mL) was added triethylamine (0.5 mL) and the reaction was heated at 50° C. for 1 h and then was allowed to cool to room temperature. Filtration and washing of the precipitates with EtOH gave 6-pentyl-2-mercapto4-methyl-nicotinonitrile as a yellow solid (1.84 g, 62.1%).

1. temperatureto cool to room temperature
2. filtrationFiltration
3. washwashing of the
4. customprecipitates with EtOH