HCID 57433140, compound → HCID 23387539, compound

HRID 489004Notes

Reaction equation

HRID 489004 reaction equation
C([O:8][C:9](=[O:28])[CH2:10][CH2:11][CH2:12][O:13][C:14](=[O:27])[C@H:15]([CH:24]([CH3:26])[CH3:25])[NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])C1C=CC=CC=1>C(OCC)(=O)C.CO.[Pd]>[C:17]([NH:16][C@H:15]([C:14]([O:13][CH2:12][CH2:11][CH2:10][C:9]([OH:28])=[O:8])=[O:27])[CH:24]([CH3:26])[CH3:25])([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]

Participants

4

Reactant 1

HCID 57433140HCID 57433140, compound

Product 1

HCID 23387539HCID 23387539, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

To a solution of 4-(N-Boc-L-valyloxy)butyric acid benzyl ester (1.2 g, 3 mmole) in ethyl acetate/methanol (5 ml/5 ml) was added palladium black (20 mg). The reaction mixture was kept under hydrogen at atmospheric pressure for 2 hr. The suspension was filtered through Celite and dried, giving the title product, 840 mg.

Workup

  1. filtrationThe suspension was filtered through Celite
  2. customdried

Sources & evidence

ORD record
ord-4a63b585d06f4c5497bf74118ad1d5f3
Source dataset
uspto-grants-2005_12
Patent number
US06974802B2

Reaction notes

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