HRID489090

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

结构：CCCCCCCCCCCCCCCCCC(=O)OCC(CCCC(=O)OC(COc1cccc2oc(C(=O)O)cc(=O)c12)COc1cccc2oc(C(=O)O)cc(=O)c12)COC(=O)[C@@H](NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(C)C

HCID23387514

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCCC(=O)OCC(CCCC(=O)OC(COc1cccc2oc(C(=O)O)cc(=O)c12)COc1cccc2oc(C(=O)O)cc(=O)c12)COC(=O)[C@@H](N)C(C)C

HCID54521872

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Dibenzyl ester of 2-[5-(N-trityl-L-valyloxymethyl)-6-stearoyloxyhexanoyloxy]-1,3-bis-(2-carboxychromon-5-yloxy)propane (238 mg, (0.17 mmol) was dissolved in ethyl acetate (1.5 ml). To the solution was added 80% acetic acid (10 ml). After two hr, the solution was evaporated and purified by column chromatography to yield 197 mg of 2-(5-(L-valyloxymethyl)-6-stearoyloxyhexanoyloxy]-1,3-bis-(2-carboxychromon-5-yloxy)propane.

WORKUP

后处理

customthe solution was evaporated
custompurified by column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3d48e1fa954445bfb5eaee12e06ffe40
来源数据集: uspto-grants-2005_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06974802B2
来源说明: uspto-grants-2005_12

反应 SMILES

C([NH:20][C@H:21]([C:25]([O:27][CH2:28][CH:29]([CH2:69][O:70][C:71](=[O:89])[CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH2:77][CH2:78][CH2:79][CH2:80][CH2:81][CH2:82][CH2:83][CH2:84][CH2:85][CH2:86][CH2:87][CH3:88])[CH2:30][CH2:31][CH2:32][C:33]([O:35][CH:36]([CH2:53][O:54][C:55]1[CH:64]=[CH:63][CH:62]=[C:61]2[C:56]=1[C:57](=[O:68])[CH:58]=[C:59]([C:65]([OH:67])=[O:66])[O:60]2)[CH2:37][O:38][C:39]1[CH:48]=[CH:47][CH:46]=[C:45]2[C:40]=1[C:41](=[O:52])[CH:42]=[C:43]([C:49]([OH:51])=[O:50])[O:44]2)=[O:34])=[O:26])[CH:22]([CH3:24])[CH3:23])(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C(O)(=O)C>C(OCC)(=O)C>[NH2:20][C@H:21]([C:25]([O:27][CH2:28][CH:29]([CH2:69][O:70][C:71](=[O:89])[CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH2:77][CH2:78][CH2:79][CH2:80][CH2:81][CH2:82][CH2:83][CH2:84][CH2:85][CH2:86][CH2:87][CH3:88])[CH2:30][CH2:31][CH2:32][C:33]([O:35][CH:36]([CH2:37][O:38][C:39]1[CH:48]=[CH:47][CH:46]=[C:45]2[C:40]=1[C:41](=[O:52])[CH:42]=[C:43]([C:49]([OH:51])=[O:50])[O:44]2)[CH2:53][O:54][C:55]1[CH:64]=[CH:63][CH:62]=[C:61]2[C:56]=1[C:57](=[O:68])[CH:58]=[C:59]([C:65]([OH:67])=[O:66])[O:60]2)=[O:34])=[O:26])[CH:22]([CH3:24])[CH3:23]