反应详情

Using the procedure as described in Example 17 (i.e., for compound 22) ethyl 8-(napthy-1-yl)-4-oxo-4H-quinolizine-3-carboxylate (23) was isolated in 51% yield by flash chromatography (ethyl acetate). M.p. 245-247° C. 1H NMR (δ, CDCl3): 1.48 (t, J=7 Hz, 3H), 4.48 (q, J=7 Hz, 2H), 6.73 (d, J=8 Hz, 1H), 7.40 (dd, J=2 Hz, J=8 Hz, 1H), 7.55-7.64 (m, 4H), 7.72 (s, 1H), 7.91 (d, J=8 Hz, 1H), 7.98-8.06 (m, 2H), 8.48 (d, J=8 Hz, 1H), 9.52 (d, J=8 Hz, 1H). MS: m/z 343.1213; required for C22H17NO3: 343.1208.