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HRID489213

反应详情

EQUATION

反应方程式

HRID 489213 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCOCC
HCID3283

Diethyl Ether

C4H10O

结构：COc1cc(NC(=O)N[C@@H]2C[C@H](O)C[C@H]2N2CCC(Cc3ccc(Cl)cc3)CC2)cc(OC)c1OC
HCID23587461

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(NC(=O)N[C@@H]2C[C@H](O)C[C@H]2N2CCC(Cc3ccc(Cl)cc3)CC2)cc(OC)c1OC.Cl
HCID23587465

未命名化合物

收率 198.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of (±)-1-{(1R,2R,4S)-2-[4-(4-chlorobenzyl)piperidin-1-yl]-4-hydroxy-cyclopentyl}-3-(3,4,5-trimethoxyphenyl)urea (102 mg, 0.20 mmol) in CH2Cl2 was treated with 1 N HCl in Et2O (0.5 mL, 0.5 mmol) and concentrated to give the product (110 mg, 100%) as a yellow solid: mp 137.0-143.0° C.; IR 3405 (br), 2935, 1685, 1606, 1554, 1507 cm−1; 1H NMR [(CD3)2SO] δ 1.48-2.12 (m, 11H), 2.54 (m, 2H), 2.90 (m, 2H), 3.45 (m, 1H), 3.58 (s, 3H), 3.71 (s, 6H), 4.22 (m, 1H), 4.48 (m, 1H), 5.16 (br s, 1H), 6.42 (d, J=9.4 Hz, 1H), 6.70 (s, 2H), 7.21 (m, 2H), 7.34 (m, 2H), 10.19 (br s, 1H); MS m/z 518 (M+H)+.

WORKUP

后处理

  1. concentrationconcentrated