HCID 178499500, compound → HCID 178510264, compound

HRID 489406Notes

Reaction equation

HRID 489406 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH:16](OC)[O:17]C)[NH:11][C:10]2=[N:21][NH:22][CH:23]=[C:9]12>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH:16]=[O:17])[NH:11][C:10]2=[N:21][NH:22][CH:23]=[C:9]12

Participants

3

Reactant 1

HCID 178499500HCID 178499500, compound

Product 1

HCID 178510264HCID 178510264, compoundYield 50.2%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

4-(2-Chlorophenyl)-5-cyano-6-dimethoxymethyl-4,7-dihydro-2H-pyrazolo[3,4-b]pyridine (4.4 g) was added to trifluoroacetic acid (20 ml) under ice-cooling and the mixture was stirred at room temperature for 2.5 hours. The reaction mixture was concentrated under reduced pressure and crystallized from ethyl acetate (50 ml) to give the title compound (1.9 g) as yellow crystals.

Workup

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customcrystallized from ethyl acetate (50 ml)

Sources & evidence

ORD record
ord-87d82e1bd67d4e3a96140cc88f93422b
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

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