反应详情

4-(2,1,3-Benzoxadiazol-4-yl)-6-(1-t-butoxycarbonylpiperidin-4-yl)-5-cyano-4,7-dihydro-2H-pyrazolo[3,4-b]pyridine (1.7 g) was added to trifluoroacetic acid (20 mL) at 0° C. and the mixture was stirred for an hour. The solvent was evaporated under reduced pressure. After alkalification with sodium bicarbonate, the mixture was extracted with ethyl acetate. The solvent was evaporated under reduced pressure and the residue was washed with acetonitrile, and the precipitated crystals were collected by filtration to give the title compound (0.83 g) as yellow crystals.

1. customThe solvent was evaporated under reduced pressure
2. extractionAfter alkalification with sodium bicarbonate, the mixture was extracted with ethyl acetate
3. customThe solvent was evaporated under reduced pressure
4. washthe residue was washed with acetonitrile
5. filtrationthe precipitated crystals were collected by filtration