Trifluoroacetic acid → HCID 178482935, compound

HRID 489439Notes

Reaction equation

HRID 489439 reaction equation
[N:1]1[O:2][N:3]=[C:4]2[C:9]([CH:10]3[C:15]([C:16]#[N:17])=[C:14]([CH2:18][N:19](C(OC(C)(C)C)=O)[CH3:20])[NH:13][C:12]4=[N:28][NH:29][CH:30]=[C:11]34)=[CH:8][CH:7]=[CH:6][C:5]=12.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[N:1]1[O:2][N:3]=[C:4]2[C:9]([CH:10]3[C:15]([C:16]#[N:17])=[C:14]([CH2:18][NH:19][CH3:20])[NH:13][C:12]4=[N:28][NH:29][CH:30]=[C:11]34)=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178482934HCID 178482934, compound

Product 1

HCID 178482935HCID 178482935, compound

Procedure

4-(2,1,3-Benzoxadiazol-4-yl)-6-((N-t-butoxycarbonyl-N-methylamino)methyl)-5-cyano-4,7-dihydro-2H-pyrazolo[3,4-b]-pyridine (0.6 g) was added to trifluoroacetic acid (10 mL) at 0° C. and the mixture was stirred for an hour. The solvent was evaporated under reduced pressure and the residue was crystallized by ethanol, and the precipitated crystals were collected by filtration to give the title compound (0.1 g) as yellow crystals.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was crystallized by ethanol
  3. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-cbb6ee5c306d4dde934fc76eff005971
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

Loading…