HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[2-(Trifluoromethyl)phenyl]piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxylate | HCID 22266189 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-[2-(Trifluoromethyl)phenyl]piperidine hydrochloride | HCID 21936970 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 1 (Step e) from tert-butyl 4-[2-(trifluoromethyl)phenyl]piperidine carboxylate (Step b) (1.64 g, 5 mmol) and satd HCl in EtOAc (50 m[). The title compound was obtained as a white solid (1.32 g). MS (ESI, pos. ion) m/z: 230 (M+1); MS (ESI, neg. ion) m/z: 228 (M−1). Calc'd for C12H15CF3N: 265.70.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06977264B2 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-b3e5d1873da449c288f3418ad915fc94 |
| Source note | uspto-grants-2005_12 |