Hydrochloric Acid → 4-[2-(Trifluoromethyl)phenyl]piperidine hydrochloride

HRID 489669Notes

Reaction equation

HRID 489669 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1.[ClH:24]>CCOC(C)=O>[ClH:24].[F:23][C:2]([F:1])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22266189tert-Butyl 4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxylate

Product 1

HCID 219369704-[2-(Trifluoromethyl)phenyl]piperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in Example 1 (Step e) from tert-butyl 4-[2-(trifluoromethyl)phenyl]piperidine carboxylate (Step b) (1.64 g, 5 mmol) and satd HCl in EtOAc (50 m[). The title compound was obtained as a white solid (1.32 g). MS (ESI, pos. ion) m/z: 230 (M+1); MS (ESI, neg. ion) m/z: 228 (M−1). Calc'd for C12H15CF3N: 265.70.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-b3e5d1873da449c288f3418ad915fc94
Source dataset
uspto-grants-2005_12
Patent number
US06977264B2

Reaction notes

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