Hydrochloric Acid → (2r)-2-Amino-3-(4-chlorophenyl)-1-{4-[2-(trifluoromethyl)-phenyl]-piperidyl}propan-1-one hydrochloride

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 1 (Step e) from N-((1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-{4-[2-(trifluoromethyl)phenyl]-piperidyl}ethyl)(tert-butoxy)-carboxamide (Step d) (1.02 g, 2.0 mmol) and satd HCl in EtOAc (50 mL). The title compound was obtained as white solid (0.89 g). MS (ESI, pos. ion) m/z: 411 (M+1); MS (ESI, neg. ion) m/z: 409 (M−1). Calc'd for C21H22ClF3N2O: 410.14.

Provenance & Evidence