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HRID489671

反应详情

EQUATION

反应方程式

HRID 489671 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccccc2C(F)(F)F)CC1
HCID69151295

未命名化合物

PRODUCTS

生成物

1
结构：Cl.N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccccc2C(F)(F)F)CC1
HCID69141649

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 1 (Step e) from N-((1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-{4-[2-(trifluoromethyl)phenyl]-piperidyl}ethyl)(tert-butoxy)-carboxamide (Step d) (1.02 g, 2.0 mmol) and satd HCl in EtOAc (50 mL). The title compound was obtained as white solid (0.89 g). MS (ESI, pos. ion) m/z: 411 (M+1); MS (ESI, neg. ion) m/z: 409 (M−1). Calc'd for C21H22ClF3N2O: 410.14.

WORKUP

后处理

  1. customThe title compound was prepared