HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 23587438, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 4-(2-Methoxyphenyl)piperidine | HCID 544738 | — |
| Reactant | Boc-D-phenylalanine | HCID 637610 | — |
| Product | HCID 23587438 | HCID 23587438 | 81,435.5% |
Reaction Steps
The title compound was prepared according to the procedure described in Example 1 (Step f) using 4-(2-methoxyphenyl)piperidine (Maybridge) (2.68 g, 0.014 mol), Boc-D-PheOH (Advanced ChemTech) (3.71 g, 0.014 mmol), HOAT (Aldrich) (1.9 g, 0.014 mol) and EDC (Advanced ChemTech) (4.02 g, 0.021 mol). Purification by silica gel chromatography (1:1 EtOAc:hexane) provided the title compound as a colorless oil (5.0 g). MS (ESI, pos. ion) m/z: 439 (M+1). Calc'd for C26H34N2O4: 438.56.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06977264B2 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-677b8bb9366c40e2b254279c5ef6b2a1 |
| Source note | uspto-grants-2005_12 |