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HRID489679

反应详情

EQUATION

反应方程式

HRID 489679 的结构方程式

REACTANTS

反应物

4
反应SMILES：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

反应SMILES：On1nnc2cccnc21
HCID181649

3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy-

C5H4N4O

反应SMILES：COc1ccccc1C1CCNCC1
HCID544738

4-(2-Methoxyphenyl)piperidine

C12H17NO

反应SMILES：CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O
HCID637610

Boc-D-phenylalanine

C14H19NO4

PRODUCTS

产物

1
反应SMILES：COc1ccccc1C1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)CC1
HCID23587438

未命名化合物

收率 81,435.5%

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 1 (Step f) using 4-(2-methoxyphenyl)piperidine (Maybridge) (2.68 g, 0.014 mol), Boc-D-PheOH (Advanced ChemTech) (3.71 g, 0.014 mmol), HOAT (Aldrich) (1.9 g, 0.014 mol) and EDC (Advanced ChemTech) (4.02 g, 0.021 mol). Purification by silica gel chromatography (1:1 EtOAc:hexane) provided the title compound as a colorless oil (5.0 g). MS (ESI, pos. ion) m/z: 439 (M+1). Calc'd for C26H34N2O4: 438.56.

WORKUP

后处理

  1. customThe title compound was prepared
  2. customPurification by silica gel chromatography (1:1 EtOAc:hexane)