反应详情

温度

4 °C

Galactaric acid (328.0 mg, 1.56 mmol) and (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine (600.0 mg, 3.40 mmol) were dissolved in 2-propanol (5 mL) and water (0.2 mL), assisted by heating and sonication. The hot solution was filtered to remove some insoluble material. The solvent was removed on a rotary evaporator, and the residue was dried under high vacuum, producing a cream-colored syrup. The syrup was dissolved in dry 2-propanol (5 mL) and cooled at 4° C. The resulting precipitate was filtered and dried under high vacuum to yield 700 mg (79.7%) of an off-white, crystalline powder, mp 131-134° C.

1. temperatureby heating
2. customsonication
3. filtrationThe hot solution was filtered
4. customto remove some insoluble material
5. customThe solvent was removed on a rotary evaporator
6. customthe residue was dried under high vacuum
7. customproducing a cream-colored syrup
8. filtrationThe resulting precipitate was filtered
9. customdried under high vacuum
10. customto yield 700 mg (79.7%) of an off-white, crystalline powder, mp 131-134° C.