反应详情

0.9 g of 3-ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole and 0.21 g of hydroxyamine hydrochloride were added to 10 ml of methanol. The mixture was heated to reflux for 4 hours. After evaporation of methanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(benzene:ether=1.1) to provide 0.80 g of the desired product(yield: 85.0%).

1. temperatureThe mixture was heated
2. temperatureto reflux for 4 hours
3. customAfter evaporation of methanol, water
4. additionwas added to the residue
5. extractionThe aqueous solution was extracted with ethylacetate
6. customAfter evaporation of ethylacetate
7. customthe residue was purified by column chromatography(benzene:ether=1.1)