1-Boc-4-(aminomethyl)piperidine → 6-amino-N-[(1-butyl-4-piperidinyl)methyl]-5-iodo-2-(methyloxy)-3-pyridinecarboxamide
Reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]([OH:12])=O)=[CH:4][C:3]=1[I:13].[CH2:14]([N:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH2:25])[CH2:20][CH2:19]1)[CH2:15][CH2:16][CH3:17].NCC1CCN(C(OC(C)(C)C)=O)CC1>>[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]([NH:25][CH2:24][CH:21]2[CH2:22][CH2:23][N:18]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:19][CH2:20]2)=[O:12])=[CH:4][C:3]=1[I:13]Participants
4
Procedure
The title compound was prepared according to the procedure of step 1 in example 1 using 6-amino-5-iodo-2-(methyloxy)-3-pyridinecarboxylic acid (step 3) and (1-butyl-4-piperidinyl)methylamine instead of 6-amino-5-chloro-2-(methyloxy)-3-pyridinecarboxylic acid and 1,1-dimethylethyl 4-(aminomethyl)-1-piperidinecarboxylate.
Sources & evidence
- ORD record
- ord-3b00230e83ee4225aec4b7da9b72154e
- Source dataset
- uspto-grants-2005_12
- Patent number
- US06979690B2
Reaction notes
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