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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 489806Generated: October 30, 2026

1-Boc-4-(aminomethyl)piperidine → 6-amino-N-[(1-butyl-4-piperidinyl)methyl]-5-iodo-2-(methyloxy)-3-pyridinecarboxamide

https://huagongshe.com/reaction/489806

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Boc-4-(aminomethyl)piperidineHCID 736817—
Reactant4-Aminomethyl-1-N-butylpiperidineHCID 10442133—
Reactant6-Amino-5-iodo-2-(methyloxy)-3-pyridinecarboxylic acidHCID 22262667—
Product6-amino-N-[(1-butyl-4-piperidinyl)methyl]-5-iodo-2-(methyloxy)-3-pyridinecarboxamideHCID 22262618—

Reaction Steps

The title compound was prepared according to the procedure of step 1 in example 1 using 6-amino-5-iodo-2-(methyloxy)-3-pyridinecarboxylic acid (step 3) and (1-butyl-4-piperidinyl)methylamine instead of 6-amino-5-chloro-2-(methyloxy)-3-pyridinecarboxylic acid and 1,1-dimethylethyl 4-(aminomethyl)-1-piperidinecarboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06979690B2
Source datasetuspto-grants-2005_12
ORD IDord-3b00230e83ee4225aec4b7da9b72154e
Source noteuspto-grants-2005_12