反应详情

温度

160 °C

A mixture of 6-amino-N-[(1-butyl-4-piperidinyl)methyl]-5-iodo-2-(methyloxy)-3-pyridinecarboxamide (step 3, 112 mg, 0.25 mmol), 2-methylimidazole (420 mg, 5 mmol), copper powder (32 mg, 0.5 mmol) and potassium carbonate (69 mg, 0.5 mmol) was heated at 140° C. for 25 min, 150° C. for 30 min and 160° C. for 45 min. After cooling, the mixture was chromatographed on a column of silica gel eluting with 25% ammonium hydroxide/methanol/dichloromethane (1:10:90) to give 35 mg (46%) of the title compound as a pale yellow solid.

1. temperatureAfter cooling
2. customthe mixture was chromatographed on a column of silica gel eluting with 25% ammonium hydroxide/methanol/dichloromethane (1:10:90)