tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 69694350, compound

HRID 489898Notes

Reaction equation

HRID 489898 reaction equation
[N:1]1([C:7]([C@@H:9]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O=[C:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]1>>[C:25]([O:24][C:22]([N:19]1[CH2:20][CH2:21][CH:16]([N:11]2[CH2:12][CH2:13][CH2:14][C@@H:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[CH2:17][CH2:18]1)=[O:23])([CH3:28])([CH3:26])[CH3:27]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 7183045HCID 7183045, compound

Product 1

HCID 69694350HCID 69694350, compoundYield 69%

Procedure

(3R)-Morpholin-4-yl-piperidin-3-yl-methanone (2.25 g, 11.4 mmol) was reacted with tert-butyl 4-oxo-1-piperidinecarboxylate (1 eq., 2.27 g) under conditions analogous to those described above for the preparation of Intermediate 1 to give (3R)-3-(morpholine-4-carbonyl)-[1,4′]bipiperidinyl-1′-carboxylic acid tert-butyl ester (3.00 g, 69%).

Sources & evidence

ORD record
ord-360533240eb74414a6f66da6a9ec2bbe
Source dataset
uspto-grants-2005_12
Patent number
US06979741B2

Reaction notes

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