反应详情

0.316 g of 3-propylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole and 0.20 g of aluminum isopropoxide were added to 10 ml of isopropanol. The mixture was heated to reflux for 48 hours. After evaporation of isopropanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(hexane: ethylacetate=3:2) to provide 0.17 g of the desired product(yield: 54.0%).

1. temperatureThe mixture was heated
2. temperatureto reflux for 48 hours
3. customAfter evaporation of isopropanol, water
4. additionwas added to the residue
5. extractionThe aqueous solution was extracted with ethylacetate
6. customAfter evaporation of ethylacetate
7. customthe residue was purified by column chromatography(hexane: ethylacetate=3:2)