1-Benzyl-3-pyrrolidinone → HCID 69694383, compound

HRID 489909Notes

Reaction equation

HRID 489909 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][C:10](=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:14]1[CH2:24][CH2:23][CH2:22][C@@H:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:15]1.C(N(CC)C(C1CCCN(C2CCN(C(C3C4C(=CC=C(C)C=4)N=C(C4C=CN=CC=4)C=3)=O)CC2)C1)=O)C>>[CH2:20]([O:19][C:17]([C@@H:16]1[CH2:22][CH2:23][CH2:24][N:14]([CH:10]2[CH2:11][CH2:12][N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:9]2)[CH2:15]1)=[O:18])[CH3:21]

Participants

4

Reactant 3

HCID 698901-Benzyl-3-pyrrolidinoneHCID 185582ethyl (3R)-piperidine-3-carboxylateHCID 69694642HCID 69694642, compound

Product 1

HCID 69694383HCID 69694383, compound

Procedure

Reductive amination of 1-benzyl-pyrrolidin-3-one with (3R)-ethyl nipecotate was carried out according to the procedure described above for Intermediate 1 to give (3R)-1-(1-benzyl-pyrrolidin-3-yl)-piperidine-3-carboxylic acid ethyl ester (containing a small amount of the isopropyl ester) as a yellow oil (1.23 g, 39%).

Sources & evidence

ORD record
ord-a9b927779ca74f83b1f41745dccacd8d
Source dataset
uspto-grants-2005_12
Patent number
US06979741B2

Reaction notes

Loading…