Hydrazine hydrate (1:1) → HCID 22037606, compound

HRID 489927Notes

Reaction equation

HRID 489927 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1O[C:9]1([C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1)[C:10](=O)[CH3:11].O.[NH2:21][NH2:22]>C(O)C>[CH3:11][C:10]1[NH:22][N:21]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[C:9]=1[C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22037365HCID 22037365, compound

Product 1

HCID 22037606HCID 22037606, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-(2-methylphenyl)-3-(4-pyridyl)-3,4-epoxy-2-butanone (step 2) (0.11 g, 0.434 mmol) and hydrazine hydrate (0.043 g, 0.868 mmol) in ethyl alcohol (50 ml) was heated at reflux for 20 hours. The solvent was removed and the resulting residue was purified by chromatography to give 4-[5-methyl-3-(2-methylphenyl)-1H-pyrazol-4-yl]pyridine: Anal. Calc'd for C16H15N3 (249.32): C, 77.08; H, 6.06; N, 16.85. Found: C, 76.66; H, 5.91; N, 16.84.

Workup

  1. temperatureat reflux for 20 hours
  2. customThe solvent was removed
  3. customthe resulting residue was purified by chromatography

Sources & evidence

ORD record
ord-89820f8aba6b49719b15d7b789936f38
Source dataset
uspto-grants-2005_12
Patent number
US06979686B1

Reaction notes

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